HCID 67167881, compound → HCID 68182172, compound

HRID 1506397Notes

Reaction equation

HRID 1506397 reaction equation
COC1C=C2C(=CC=1)C1OC(C3ON=C(C4C=CC=CC=4)C=3C(F)(F)F)=NC=1CC2.[CH3:31][O:32][C:33]1[CH:34]=[C:35]2[C:40](=[CH:41][CH:42]=1)[C:39](=[O:43])[CH:38]([NH:44][C:45]([C:47]1[C:51]([C:52]([F:55])([F:54])[F:53])=[C:50]([C:56]3[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=3)[O:49][N:48]=1)=O)[CH2:37][CH2:36]2>>[CH3:31][O:32][C:33]1[CH:34]=[C:35]2[C:40](=[CH:41][CH:42]=1)[C:39]1[O:43][C:45]([C:47]3[C:51]([C:52]([F:53])([F:55])[F:54])=[C:50]([C:56]4[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=4)[O:49][N:48]=3)=[N:44][C:38]=1[CH2:37][CH2:36]2

Participants

3

Reactant 2

HCID 67167881HCID 67167881, compoundHCID 68182134HCID 68182134, compound

Product 1

HCID 68182172HCID 68182172, compound

Procedure

The titled compound was prepared using the experimental protocol described for Preparation 43B employing N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-5-phenyl-4-(trifluoromethyl)isoxazole-3-carboxamide (Preparation 49A). 1H NMR (400 MHz, CDCl3) δ ppm 7.73 (2H, d, J=7.26 Hz), 7.51-7.60 (3H, m), 7.48 (1H, d, J=9.02 Hz), 6.78-6.84 (2H, m), 3.82 (3H, s), 3.08-3.17 (2H, m), 2.95-3.03 (2H, m).

Sources & evidence

ORD record
ord-7ae36cc7690f4667aea43e1fdf09e66a
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

Loading…