反应详情

Following the same procedure to synthesize 2-(2-amino-1H-benzo[d]imidazol-6-ylcarbamoyl)benzoic acid hydrochloride, tert-butyl 6-amino-2-(bis(tert-butoxycarbonyl)amino)-1H-benzo[d]imidazole-1-carboxylate (0.100 g, 0.223 mmol) was reacted with 4,5,6,7-tetrachloroisobenzofuran-1,3-dione (0.064 g, 0.223 mmol) to give the title compound (0.081 g, 77% yield) as a yellow solid. 1H NMR (300 MHz, CD3OD) δ 7.32 (s, 2H), δ 7.12 (s, 1H) ppm; 13C NMR (75 MHz, CD3OD) δ 198.8, 165.5, 152.2, 134.7, 133.5, 130.6, 130.2, 129.6, 126.5, 118.5, 112.5, 106.7 ppm; HRMS (ESI) Calcd for C15H8Cl4N4O3 (M+) 431.9351. Found 431.9359.