反应详情

Trifluoroacetic acid (20 mL) was added to chloroform solution (20 mL) of 4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(3R)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl]oxy}phenyl)-1H-pyridin-2-one (3.14 g, Example 121), and stirred at room temperature for an hour. After concentrating the reaction liquid, 1N sodium hydroxide solution was added thereto, followed by extraction with chloroform two times. The organic layer was washed with saturated brine, dried over anhydrous potassium carbonate, and the solvent was concentrated under reduced pressure to provide the title compound (2.65 g, 83%).

1. concentrationAfter concentrating
2. customthe reaction liquid, 1N sodium hydroxide solution
3. additionwas added
4. extractionfollowed by extraction with chloroform two times
5. washThe organic layer was washed with saturated brine
6. dry with materialdried over anhydrous potassium carbonate
7. concentrationthe solvent was concentrated under reduced pressure