反应详情

Following the procedure for 2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-7,8-dihydroquinolin-5(6H)-one, tert-butyl(1-(4-(1-(2-amino-2-oxoethyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (10 mg, 0.02 mmol) was reacted to afford the title compound (10 mg, quantitative). LCMS (Method A): RT=3.43 min, M-NH2=412. 1H NMR (500 MHz, MeOD): 7.39 (2H, d), 7.36 (2H, d), 7.34 (1H,S), 7.28-7.26 (3H, m), 7.18-7.17 (m, 2H), 5.01 (2H, s), 4.72 (2H, s), 2.76-2.70 (m, 2H), 2.57-2.51 (m, 2H), 2.25-2.16 (m, 1H), 1.98-1.89 (m, 1H).

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