反应详情

A solution of tert-butyl(1-(4-(2-hydrazono-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (20 mg, 0.04 mmol) in triethyl orthoformate (1 mL) was heated at 150° C. for 10 min under microwave irradiation. The reaction mixture was concentrated to dryness under reduced pressure. The resulting residue was purified by silica gel chromatography (gradient 0 to 2% MeOH in dichloromethane) to give the title compound (3 mg, 15%). 1H NMR (500 MHz, CDCl3): 8.68 (1H, s), 7.75 (1H, s), 7.34-7.26 (7H, m), 7.22-7.20 (2H,m), 5.70 (2H, s), 5.02 (1H, br s), 2.55-2.25 (4H, m), 2.10-2.03 (1H, m), 1.86-1.78 (1H, m), 1.44-1.15 (9H, br).

1. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
2. customThe resulting residue was purified by silica gel chromatography (gradient 0 to 2% MeOH in dichloromethane)