反应详情

Following the procedure for 1-(6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)ethanone, 1-((1H-imidazol-2-yl)ethyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one, tert-butyl(1-(4-(1-(cyanomethyl)-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (5 mg, 0.01 mmol) was reacted to afford the two title compounds (1 mg, 25% and 2 mg, 41%). LCMS: RT=3.99 min, M-16=380. 1H NMR (500 MHz, MeOD): 7.20-7.13 (8H, m), 7.09-7.07 (2H, m), 4.46 (2H, t), 3.54 (2H, s), 3.22 (2H, t), 2.46-2.40 (2H, m), 2.17-2.11 (2H, m), 1.97-1.94 (1H, m), 1.66-1.62 (1H, m). LCMS (Method A): RT=3.99 min, M-16=398. 1H NMR (500 MHz, D2O): 8.39 (2H, s), 7.27-7.22 (7H, m), 7.11-7.09 (2H, m), 6.89 (1H, s), 4.78 (2H, s), 4.48 (2H, t), 4.00 (2H, s), 3.50 (2H, t), 2.65-2.60 (2H, m), 2.53-2.47 (2H, m), 2.09-2.05 (1H, m), 1.86-1.79 (1H, m).

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