反应详情

A solution of (E)-tert-butyl(1-(4-(2-(2-(2,2-difluoroacetyl)hydrazono)-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (80 mg, 0.142 mmol) in p-xylene (1 ml) was heated to 150° C. for 15 minutes under microwave irradiation. The resulting reaction mixture was concentrated to dryness under reduced pressure and purified by Biotage silica gel chromatography (gradient 0% to 2% methanol in dichloromethane) to give the title compound (15 mg, 20%). LCMS (Method D): RT=1.529 min, M+1=546.

1. customThe resulting reaction mixture
2. concentrationwas concentrated to dryness under reduced pressure
3. custompurified by Biotage silica gel chromatography (gradient 0% to 2% methanol in dichloromethane)