反应详情

The title compound (39.4 mg, 82% yield) was prepared as a brown solid from 6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthoic acid (37.6 mg, 0.1 mmol) and 4-methyl-o-phenylenediamine (14.6 mg, 0.12 mmol) by an analogous procedure to that described in example 16. 1H NMR (DMSO-d6) (isomer ratio 0.77/0.23) δ 2.21 (s, 1H, Ar—CH3), 4.01 (s, 6H, 2×OCH3), 4.77 (s, 0.23×2H, benzene-NH2), 4.89 (s, 0.77×2H, benzene-NH2), 6.46 (d, J=7.6 Hz, 0.77×1H, Ar—H), 6.64 (s, 0.77×1H, Ar—H), 6.73 (d, J=7.9 Hz, 0.23×1H, Ar—H), 6.81 (s, 0.23×1H, Ar—H), 7.24 (d, J=8.1 Hz, 1H, Ar—H), 7.41 (s, 1H, Ar—H), 7.58-7.66 (m, 3H, Ar—H), 7.85 (d, J=6.7 Hz, 1H, Ar—H), 7.97 (s, 1H, Ar—H), 8.08 (d, J=7.9 Hz, 1H, Ar—H), 8.38 (d, J=9.0 Hz, 1H, Ar—H), 8.54 (s, 1H, Ar—H), 9.77 (s, 1H, benzene-NH). LC-MS (m/z) 481 (M+1).