HCID 17786652, compound → (E)-N-[2-Nitro-4-(2-trifluoromethyl-pyridin-4-yl)-phenyl]-3-(tetrahydro-pyran-4-yl)-acrylamide

HRID 1512173Notes

Reaction equation

HRID 1512173 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[CH:7]=[CH:6][C:5]=1[NH2:20])([O-:3])=[O:2].[O:21]1[CH2:26][CH2:25][CH:24](/[CH:27]=[CH:28]/[C:29](O)=[O:30])[CH2:23][CH2:22]1>>[N+:1]([C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([C:16]([F:19])([F:17])[F:18])[CH:11]=2)[CH:7]=[CH:6][C:5]=1[NH:20][C:29](=[O:30])/[CH:28]=[CH:27]/[CH:24]1[CH2:25][CH2:26][O:21][CH2:22][CH2:23]1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 17786652HCID 17786652, compoundHCID 67527994HCID 67527994, compound

Product 1

HCID 68769915(E)-N-[2-Nitro-4-(2-trifluoromethyl-pyridin-4-yl)-phenyl]-3-(tetrahydro-pyran-4-yl)-acrylamide

Procedure

Following the procedure as described in Example 3, STEP B, the title compound was prepared from 2-nitro-4-(2-trifluoromethyl-pyridin-4-yl)-phenylamine (84.5 mg, 0.298 mmol, as prepared in the previous step) and (E)-3-(tetrahydro-pyran-4-yl)-acrylic acid (prepared as described in PCT Publication WO 2005/101989 (A2, A3), 60.5 mg, 0.388 mmol) and was obtained as a yellow solid.

Workup

  1. customwas obtained as a yellow solid

Sources & evidence

ORD record
ord-84cdebb1f65146fb8a55a083d1e5e260
Source dataset
uspto-grants-2012_07
Patent number
US08217060B2

Reaction notes

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