反应详情

温度

0 °C

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde (0.375 g, 1.41 mmol) was dissolved in THF (3.75 mL) and cooled to 0° C. under N2 atmosphere. Allylmagnesium bromide (1 M in Et20, 1.55 mL, 1.55 mmol) was added and the reaction stirred at 0° C. for 1.5 hours. Additional allylmagnesium bromide (1 M in Et2O, 0.8 mL, 0.80 mmol) was added, and the reaction was stirred for 30 minutes at 0° C. The mixture was quenched with saturated aqueous NH4Cl and extracted with EtOAc. The combined organic layers were dried and concentrated and the residue was purified by silica gel chromatography (0-50% EtOAc in hexanes) to give the title compound.

1. stirringthe reaction was stirred for 30 minutes at 0° C
2. customThe mixture was quenched with saturated aqueous NH4Cl
3. extractionextracted with EtOAc
4. customThe combined organic layers were dried
5. concentrationconcentrated
6. customthe residue was purified by silica gel chromatography (0-50% EtOAc in hexanes)