Hydrochloric Acid → 5,2'-Bistrifluoromethyl-biphenyl-3,4-diamine

Temperature

80 °C

5-Nitro-3,2′-bis-trifluoromethyl-biphenyl-4-ylamine (11.3 g, 32.5 mmol, as prepared in the previous step) was placed in a 500 mL round-bottom flask equipped with a magnetic stir bar. Anhydrous EtOH (150 mL) and 3M aq HCl (30 mL) were added via syringe. Iron powder (9.07 g, 162 mmol) was added, and the mixture was stirred at 80° C. for 6 h. The reaction was cooled to RT and filtered through a pad of Celite. The filter cake was washed with MeOH (300 mL). The solvent was removed under reduced pressure. The residue was dissolved in EtOAc (150 mL) and washed with water (150 mL). The aqueous layer was diluted with brine (100 mL) and extracted twice with EtOAc (50 mL). The combined organic extracts were washed with satd aq NaHCO3, dried over MgSO4, filtered, and the solvent was removed under reduced pressure. The material was used directly in the next step without further purification.

1. customwas placed in a 500 mL round-bottom flask
2. customequipped with a magnetic stir bar
3. temperatureThe reaction was cooled to RT
4. filtrationfiltered through a pad of Celite
5. washThe filter cake was washed with MeOH (300 mL)
6. customThe solvent was removed under reduced pressure
7. dissolutionThe residue was dissolved in EtOAc (150 mL)
8. washwashed with water (150 mL)
9. additionThe aqueous layer was diluted with brine (100 mL)
10. extractionextracted twice with EtOAc (50 mL)
11. washThe combined organic extracts were washed with satd aq NaHCO3
12. dry with materialdried over MgSO4
13. filtrationfiltered
14. customthe solvent was removed under reduced pressure
15. customThe material was used directly in the next step without further purification

ORD record

ord-af59178b91e84d29a64afa409769bd0d

Source dataset

uspto-grants-2012_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08232409B2