反应详情

The title compound 101 was prepared using the same procedure described in step 2 of Example 54 by replacing compound 54A and compound 2C with compound 93 and compound 96D, respectively: 1H NMR (400 MHz, DMSO-D6) δ ppm 12.80 (1H, s), 9.61 (1H, s), 8.03 (1H, d), 7.79 (1H, d), 7.60 (1H, d), 7.55 (1H, d), 7.44-7.51 (1H, m), 7.39-7.43 (1H, m), 7.33-7.38 (2H, m), 7.02 (1H, t), 6.90-6.98 (2H, m), 6.70 (1H, dd), 4.93 (2H, s), 3.93 (2H, t), 3.86 (2H, t), 3.67-3.75 (2H, m), 3.26-3.37 (2H, m), 3.06-3.20 (2H, m), 2.99 (2H, t), 2.76-2.93 (7H, m), 1.86-1.99 (2H, m); LCMS (APCI) m/e 681 (M+H).