反应详情

Using the conditions of General Procedure B for Suzuki Coupling and Hydrolysis in Parallel Mode, 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (which may be prepared as described for Intermediate 6; 89 mg, 0.2 mmol) was reacted with 3-nitrophenylboronic acid (available from Aldrich Chemical Company, Inc.; 67 mg, 0.4 mmol). The resulting ester was hydrolyzed and the acid was purified to give 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-3′-nitro-biphenyl-2-carboxylic acid (36 mg, 38%). 1H NMR (400 MHz, DMSO-d6) δ 8.46-8.51 (m, 2H), 8.18-8.39 (m, 4H), 8.06-8.15 (m, 1H), 7.87 (d, J=7.0 Hz, 1H), 7.73-7.79 (m, 2H), 7.63-7.68 (m, 1H).

1. customthe acid was purified