反应详情

The title compound was prepared in the same manner as described for intermediate 58 using ethyl 6-(4-chlorophenyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (400 mg, 1.163 mmol), Ethanol (6 mL), THF (1 mL), and added sodium hydroxide (1.939 mL, 5.82 mmol) wherein the reaction time was 2 h. The final product was collected as 330 mg (90%). LCMS E-S (M+H)=315.8. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (d, J=6.8 Hz, 6 H), 5.26-5.47 (m, 1 H), 7.62 (d, J=8.6 Hz, 2 H), 8.20 (s, 1 H), 8.28 (d, J=8.6 Hz, 2 H), 8.38 (s, 1 H), 14.03 (s, 1 H).

1. customThe final product was collected as 330 mg (90%)