反应详情

A solution of methyl 4′-(2-aminopyrimidin-5-yl)-3′-fluoro-[1,1′-biphenyl]-2-carboxylate (218 mg, 0.67 mmol) in NaOH (8 mL, 2 N) and THF (8 mL) was stirred at 80° Celsius for 48 hours, and then concentrated to dryness. The residue was acidified with 2 N HCl. The precipitate was collected by filtration and washed with water several times, and dried in vacuo to afford the desired product (220 mg, 106%). The crude product was used without further purification. MS (ESI): mass calcd. for C17H12FN3O2, 309.09; m/z found, 309.9 [M+H]+.

1. concentrationconcentrated to dryness
2. filtrationThe precipitate was collected by filtration
3. washwashed with water several times
4. customdried in vacuo