反应详情

To a solution of 4-(1,3-thiazol-5-yl)-7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidine (2.12 g, 6.38 mmol) in THF (70 mL) at −78° C. was added 2.5 M n-butyllithium in hexane (3.06 mL) slowly dropwise. After stirring for 30 minutes, N-methoxy-2-[(4-methoxybenzyl)oxy]-N-methylacetamide (2.29 g, 9.56 mmol) was added. The reaction was continued for 30 minutes following the addition, at −78° C., then the cooling bath was removed and the reaction was quenched with saturated ammonium chloride and extracted with ether. The extracts were dried with sodium sulfate and concentrated in vacuo. The crude mixture was purified by flash column chromatography (ethyl acetate/hexanes) to afford desired product (2.16 g, 66%).

1. waitThe reaction was continued for 30 minutes
2. additionthe addition
3. customat −78° C., then the cooling bath was removed
4. customthe reaction was quenched with saturated ammonium chloride
5. extractionextracted with ether
6. dry with materialThe extracts were dried with sodium sulfate
7. concentrationconcentrated in vacuo
8. customThe crude mixture was purified by flash column chromatography (ethyl acetate/hexanes)