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HRID1527443

反应详情

EQUATION

反应方程式

HRID 1527443 的结构方程式

REACTANTS

反应物

2
结构：[N-]=[N+]=[N-].[Na+]
HCID33557

未命名化合物

结构：Cc1ccc(S(=O)(=O)OC[C@@H]2C[C@H]3C[C@H]3N2C(=O)OC(C)(C)C)cc1
HCID86673858

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1[C@H](CN=[N+]=[N-])C[C@H]2C[C@H]21
HCID86673859

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

CONDITIONS

反应条件

温度
65 °C

PROCEDURE

实验过程

A mixture of (1R,3S,5R)-3-(toluene-4-sulfonyloxymethyl)-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester (0.400 g, 1.08 mmol) and NaN3 (0.420 g, 6.47 mmol) in dry DMSO (8 mL) was stirred at 65° C. overnight. After cooling, the mixture was diluted with Et2O and washed with water (×3) and brine (×2). The organics were dried (phase separator) and concentrated in vaccuo to give the title compound as a colorless oil. MS (LC-MS): 239.0 [M+H]+; tR (HPLC conditions k): 3.78 min. The material thus obtained was used in the next step without further purification.

WORKUP

后处理

  1. temperatureAfter cooling
  2. washwashed with water (×3) and brine (×2)
  3. customThe organics were dried (phase separator)
  4. concentrationconcentrated in vaccuo