反应详情

To a solution of tert-butyl 5-(1-methyl-1H-pyrazol-5-yl)-3,4-dihydropyridine-1(2H)-carboxylate (800 mg, 3.00 mmol) in MeOH (20 mL) was added 10% Pd/C (80 mg). The reaction mixture was stirred under H2 (1 atm) for 16 h. After concentration, the residue was purified by silica gel chromatography eluting with a 0-30% gradient of EtOAc in petroleum ether to give tert-butyl 3-(1-methyl-1H-pyrazol-5-yl)piperidine-1-carboxylate (0.68 g, 86% yield) as pale yellow oil. LCMS (ESI) m/z: 265.2 [M+H+]

1. concentrationAfter concentration
2. customthe residue was purified by silica gel chromatography
3. washeluting with a 0-30% gradient of EtOAc in petroleum ether