反应详情

10-bromo-5-ethoxycarbonyl-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one (400 mg) obtained in Example 98 was suspended in ethanol (10 ml), and 1N sodium hydroxide (3 ml) was added. The mixture was stirred at room temperature for 12 hours, and the solvent was evaporated under reduced pressure. To tne residue was added IN hydrochloric acid to pH 1, and the crystals precipitated were recovered by filtration, and washed with ethanol and ether to obtain the title compound (310 mg, 83%).

1. customthe solvent was evaporated under reduced pressure
2. additionTo tne residue was added IN hydrochloric acid to pH 1
3. customthe crystals precipitated
4. filtrationwere recovered by filtration
5. washwashed with ethanol and ether