HRID1531484

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)CN1CCCc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(OCCCOCc4ccccc4OC)cc3)cc21

HCID69486566

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CN1CCCc2ccc(COC3CNCCC3c3ccc(OCCCOCc4ccccc4OC)cc3)cc21

HCID69486004

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID10421208

Zinc bromide

Br2Zn

溶剂HCID6365

1,1-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

In analogy to the procedure described in example 1(e), the (3RS,4RS)-3-(1-ethoxycarbonylmethyl-1,2,3,4-tetrahydro-quinolin-7-ylmethoxy)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester was deprotected with zinc bromide in dichloroethane to yield the (3RS,4RS)-[7-(4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidin-3-yloxymethyl)-3,4-dihydro-2H-quinolin-1-yl]-acetic acid ethyl ester as a yellow oil; MS: 603 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4d47f6e8c7614ac6963d79a9b24e0078
来源数据集: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06197959B1
来源说明: uspto-grants-2001_03

反应 SMILES

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH2:23][O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[O:32][CH3:33])=[CH:16][CH:15]=2)[CH:10]([O:34][CH2:35][C:36]2[CH:45]=[C:44]3[C:39]([CH2:40][CH2:41][CH2:42][N:43]3[CH2:46][C:47]([O:49][CH2:50][CH3:51])=[O:48])=[CH:38][CH:37]=2)[CH2:9]1)=O)(C)(C)C>ClC(Cl)C.[Br-].[Zn+2].[Br-]>[CH2:50]([O:49][C:47](=[O:48])[CH2:46][N:43]1[C:44]2[C:39](=[CH:38][CH:37]=[C:36]([CH2:35][O:34][CH:10]3[CH:11]([C:14]4[CH:15]=[CH:16][C:17]([O:20][CH2:21][CH2:22][CH2:23][O:24][CH2:25][C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=5[O:32][CH3:33])=[CH:18][CH:19]=4)[CH2:12][CH2:13][NH:8][CH2:9]3)[CH:45]=2)[CH2:40][CH2:41][CH2:42]1)[CH3:51]