HRID1531555

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID70223394

未命名化合物

PRODUCTS

产物

HCID70226124

未命名化合物

收率 90.5%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

The title compound was prepared essentially as described in EXAMPLE 2.1 StepE starting from {2-[2-(3,5-dimethylphenyl)-5-nitro-1H-indol-3-yl]-ethyl}-[4-(4-amino(dimethanesulfonyl)phenyl)butyl]-carbamic acid tert-butyl ester (330 mg) and using 10% palladium on carbon as catalyst to give the title compound (286 mg).

WORKUP

后处理

customThe title compound was prepared essentially

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-9c0ead58e03b448fadee5f49f3d750af
来源数据集: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06197975B1
来源说明: uspto-grants-2001_03

反应SMILES

[C:1]([O:5][C:6](=[O:49])[N:7]([CH2:27][CH2:28][C:29]1[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([N+:38]([O-])=O)[CH:36]=2)[NH:31][C:30]=1[C:41]1[CH:46]=[C:45]([CH3:47])[CH:44]=[C:43]([CH3:48])[CH:42]=1)[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[C:14]([S:19]([CH3:22])(=[O:21])=[O:20])[C:13]=1[S:23]([CH3:26])(=[O:25])=[O:24])([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:49])[N:7]([CH2:27][CH2:28][C:29]1[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([NH2:38])[CH:36]=2)[NH:31][C:30]=1[C:41]1[CH:42]=[C:43]([CH3:48])[CH:44]=[C:45]([CH3:47])[CH:46]=1)[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[C:14]([S:19]([CH3:22])(=[O:20])=[O:21])[C:13]=1[S:23]([CH3:26])(=[O:25])=[O:24])([CH3:2])([CH3:4])[CH3:3]