4-Methylmorpholine → (1,1-dimethylethyl) (S)-[1-methyl-2-[(2-methyl-2-propenyl)amino]-2-oxoethyl]carbamate

HRID 1532450Notes

Reaction equation

HRID 1532450 reaction equation
[CH3:1][C:2]([CH3:13])([O:4][C:5]([NH:7][C@H:8]([C:10]([OH:12])=O)[CH3:9])=[O:6])[CH3:3].Cl.[CH3:15][C:16](=[CH2:19])[CH2:17][NH2:18].CN1CCOCC1>>[CH3:9][C@H:8]([NH:7][C:5](=[O:6])[O:4][C:2]([CH3:1])([CH3:3])[CH3:13])[C:10]([NH:18][CH2:17][C:16]([CH3:19])=[CH2:15])=[O:12]

Participants

4

Reactant 3

HCID 79724-MethylmorpholineHCID 85082Tert-butoxycarbonylalanineHCID 119537722-Methylallylamine hydrochloride

Product 1

HCID 53642955(1,1-dimethylethyl) (S)-[1-methyl-2-[(2-methyl-2-propenyl)amino]-2-oxoethyl]carbamateYield 99.9%

Procedure

To a cooled (0° C.) mixture of 18.9 parts of (S)-N-[(1,1,-dimethylethoxy)carbonyl]-alanine, 10.8 parts of 2-methyl-2-propen-1-amine monohydrochloride, 27.0 parts of 1-hydroxy-1H-benzotriazle hydrate and tetaahydrofuran, there were added 10.1 parts of N-methylmorpholine and, after 20 min, 20.6 parts of N,N-methanetetraylbis-[cyclohexanamine] under a nitrogen atmosphere. The whole was kept at 0° C. for 1 hour and at room temperature for 12 hours. The solvent was evaporated and the residue was partitioned between dichloromethane and NaHCO3 (sat.). The organic layer was separated, washed with NaCl (sat), dried, filtered and evaporated, yielding 24.2 parts (99.9%) of (1,1-dimethylethyl) (S)-[1-methyl-2-[(2-methyl-2-propenyl)amino]-2-oxoethyl]carbamate (interm. 63).

Workup

  1. temperatureTo a cooled
  2. waitThe whole was kept at 0° C. for 1 hour and at room temperature for 12 hours
  3. customThe solvent was evaporated
  4. customthe residue was partitioned between dichloromethane and NaHCO3 (sat.)
  5. customThe organic layer was separated
  6. washwashed with NaCl (sat)
  7. customdried
  8. filtrationfiltered
  9. customevaporated

Sources & evidence

ORD record
ord-00cffd0a18ee4019b450b8679fe93664
Source dataset
uspto-grants-2001_03
Patent number
US06201119B1

Reaction notes

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