反应详情

A solution of 43.79 g acetic acid 3-(4-tert-butyl-phenyl)-2-methyl-propenyl ester in 200 ml of THF was cooled to −70° C. A solution of 27.16 g potassium-tert-butoxide in 200 ml of THF was added at −70° C. during 20 min. and the resulting reaction mixture was stirred for 90 min. at the same temperature. Then a solution of 53.00 g 4-oxo-undecanoyl chloride in 200 ml of THF was dropped in and the reaction mixture was stirred for another 2.5 hours at −70° C. Then the reaction mixture was diluted with ether, washed with saturated NaHCO3 and brine. The organic phase was dried, filtered and evaporated to dryness. The residue was thin-layer distilled and purified by chromatography to yield 25.73 g of a yellow oil.

1. customthe resulting reaction mixture
2. stirringwas stirred for another 2.5 hours at −70° C
3. washwashed with saturated NaHCO3 and brine
4. customThe organic phase was dried
5. filtrationfiltered
6. customevaporated to dryness
7. distillationdistilled
8. custompurified by chromatography