反应详情

{5-[(3-Chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester was treated with TFA (2 mL) for 2 hours, concentrated, and purified by preparative LCMS to give the title compound. 1H NMR (d6-DMSO) δ7.72 (m, 2H), 7.46 (m, 2H), 7.23 (m, 4H), 7.16 (d, 1H), 7.10 (d, 1H), 6.76 (dd, 1H), 4.82 (s, 2H), 4.32 (s, 2H), 2.67 (t, 2H), 1.72 (m, 2H), 0.94 (t, 3H). MS calculated for C25H23FClN3O4S—H: 514, observed: 514.

1. concentrationconcentrated
2. custompurified by preparative LCMS