反应详情

{5-[(Cyclohexyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester was treated with TFA (2 mL) for 2 hours, concentrated, and purified by preparative LCMS to give the title compound. 1H NMR (d6-DMSO) δ7.81 (m, 1H), 7.42 (m, 3H), 7.08 (d, 1H), 6.79 (dd, 1H), 4.98 (s, 2H), 4.11 (m, 1H), 2.72 (t, 2H), 1.79 (m, 4H), 1.65 (m, 2H), 1.31 (m, 3H), 0.99 (m, 5H), 0.79 (m, 1H). MS calculated for C24H28FN3O4S—H: 472, observed: 472.

1. concentrationconcentrated
2. custompurified by preparative LCMS