反应详情

{5-[(4-Trifluoromethoxy-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester was treated with TFA (2 mL) for 2 hours, concentrated, and purified by preparative LCMS to give the title compound. 1H NMR (d6-DMSO) δ7.72 (m, 2H), 7.44 (m, 4H), 7.23 (m, 3H), 7.16 (d, 1H), 6.79 (m, 1H), 4.88 (s, 2H), 4.54 (s, 2H), 2.68 (t, 2H), 1.72 (m, 2H), 0.95 (t, 3H). MS calculated for C26H23F4N3O5S—H: 564, observed: 564.

1. concentrationconcentrated
2. custompurified by preparative LCMS