反应详情

To a stirred solution of 10.5 g. (0.0664 mole) of 4-hydroxy-6-methyl-3-mercapto-2-pyrone in 50 ml. of pyridine was added 9.60 g. (0.0664 mole) of p-fluorobenzyl chloride in one portion. The reaction was slightly exothermic, the temperature rising from 25° to 34°C. The reaction mixture was then allowed to stand at room temperature for four hours and at the end of this period was poured into a mixture of ice and 100 ml. of concentrated hydrochloric acid. The gummy precipitate was extracted with methylene chloride and the extract dried over anhydrous magnesium sulfate. The solvent was removed by evaporation in vacuo, leaving a light yellow oil, which crystallized upon cooling, weight 12.5 g. (71 percent). This was recrystallized from a solvent system of methylcyclohexane, benzene and ethanol to give light yellow crystals, m.p. 114.5°-118.5°C.; weight 7.20 g. Recrystallization from benzene gave the pure 3-(p-fluorobenzylthio)-4-hydroxy-6-methyl-2-pyrone as a pale yellow, crystalline solid, m.p. 118°-122°C.

1. customrising from 25° to 34°C
2. additionwas poured into a mixture of ice and 100 ml
3. extractionThe gummy precipitate was extracted with methylene chloride
4. dry with materialthe extract dried over anhydrous magnesium sulfate
5. customThe solvent was removed by evaporation in vacuo
6. customleaving a light yellow oil, which
7. customcrystallized
8. temperatureupon cooling
9. customThis was recrystallized from a solvent system of methylcyclohexane, benzene and ethanol
10. customto give light yellow crystals, m.p. 114.5°-118.5°C.
11. customRecrystallization from benzene