反应详情

0.20 g (0.52 mMol) 4-[2-(4-fluoro-benzoylamino)-4-methoxy-benzothiazol-7-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester were dissolved in 5 ml 2.5 M HCl/MeOH and heated to reflux for 1.5 h. The reaction mixture was concentrated in vacuo and taken up in 4 ml isopropanol. The suspension formed was filtered and the material on the filter was washed with diethyl ether and dried in vacuo. One obtained 200 mg (92%) 4-fluoro-N-[4-methoxy-7-(1,2,3,6-tetrahydro-pyridin-4-yl)-benzothiazol-2-yl]-benzamide hydrochloride (1:1) as an off-white solid. F.p.: 268-275° C.

1. temperatureheated
2. temperatureto reflux for 1.5 h
3. concentrationThe reaction mixture was concentrated in vacuo
4. customThe suspension formed
5. filtrationwas filtered
6. washthe material on the filter was washed with diethyl ether
7. customdried in vacuo