反应详情

To a solution of 0.14 g (0.94 mmol) of 4-[2-(4-fluoro-benzoylamino)-4-methoxy-benzothiazol-7-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester in 6.0 ml of methanol and 6.0 ml THF 90.0 mg of Pd/C (10%) were added. The reaction mixture was hydrogenated at 60° C. for 4 h, then filtered and evaporated to dryness in vacuo. The residue was crystallized from diethyl ether to yield 0.105 g (75%) 4-[2-(4-fluoro-benzoylamino)-4-methoxy-benzothiazol-7-yl]-piperidine-1-carboxylic acid tert-butyl ester as a white solid. F.p.: 222-223° C.

1. filtrationfiltered
2. customevaporated to dryness in vacuo
3. customThe residue was crystallized from diethyl ether