反应详情

0.08 g (0.14 mMol) 4-{4-methoxy-2-[(2-morpholin-4-yl-pyridine-4-carbonyl)-amino]-benzothiazol-7-yl}-piperidine-1-carboxylic acid tert-butyl ester were dissolved in 2 ml 2.5 M HCl/MeOH and heated to reflux for 1.5 h. The reaction mixture was concentrated in vacuo and taken up in 3 ml isopropanol. The suspension formed was filtered and the material on the filter was washed with diethyl ether and dried in vacuo. One obtained 54 mg (71%) N-(4-methoxy-7-piperidin-4-yl-benzothiazol-2-yl)-2-morpholin-4-yl-isonicotinamide 1:2 hydrochloride as a yellow solid. F.p.: 260-270° C. (dec.).

1. temperatureheated
2. temperatureto reflux for 1.5 h
3. concentrationThe reaction mixture was concentrated in vacuo
4. customThe suspension formed
5. filtrationwas filtered
6. washthe material on the filter was washed with diethyl ether
7. customdried in vacuo