反应详情

To a solution of 0.30 g (0.62 mMol) of 4-{4-methoxy-2-[(2-methyl-pyridine-4-carbonyl)-amino]-benzothiazol-7-yl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester in 15.0 ml of methanol and 15.0 ml THF 160.0 mg of Pd/C (10%) were added. The reaction mixture was hydrogenated at 60° C. for 10 h, then filtered and evaporated to dryness in vacuo. The residue was triturated in diethyl ether to yield 0.15 g (53%) 4-{4-methoxy-2-[(2-methyl-pyridine-4-carbonyl)-amino]-benzothiazol-7-yl}-piperidine-1-carboxylic acid tert-butyl ester as a white solid. F.p.: 155-157° C.

1. filtrationfiltered
2. customevaporated to dryness in vacuo
3. customThe residue was triturated in diethyl ether