4'-Hydroxyacetophenone → HCID 13376806, compound

HRID 1582705Notes

Reaction equation

HRID 1582705 reaction equation
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1)=[O:3].F[C:12]1[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=1.FC1C=CC(OC2C=CC(C(=O)C)=CC=2)=CC=1>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:10][C:7]2[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH3:1])=[CH:5][CH:6]=2)=[CH:13][CH:14]=1

Participants

4

Reactant 3

HCID 74694'-HydroxyacetophenoneHCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 27590561-[4-(4-fluorophenoxy)phenyl]ethanone

Product 1

HCID 13376806HCID 13376806, compound

Procedure

1H NMR (DMSO-d6): δ 15.0 (bs, 2H), 9.25 (s, 1H), 8.18 (s, 1H), 7.98 (d, J=8.4 Hz, 2H), 7.77 (d, J=9.0 Hz, 2H), 7.29 (d, J=8.7 Hz, 2H), 7.21 (d, J=8.7 Hz, 2H); mp 230-232° C. The intermediate 1-[4-(4-trifluoromethylphenoxy)phenyl]ethanone was prepared from 4-hydroxyacetophenone and 4-fluorobenzotrifluoride using the method described for the synthesis of 1-[4-(4-fluorophenoxy)phenyl]ethanone.

Sources & evidence

ORD record
ord-a5dab5548c8046c3899cfdfe23c7880d
Source dataset
uspto-grants-2004_05
Patent number
US06737418B2

Reaction notes

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