HRID1583442

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID16646

4-Methoxyphenyl glycidyl ether

C10H12O3

结构：COC(=O)C1=C(C)NC2=C(C(=O)CNC2)C1c1c(F)c(F)c(F)c(F)c1F

HCID13061758

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1=C(C)NC2=C(C(=O)CN(CC(O)COc3ccc(OC)cc3)C2)C1c1c(F)c(F)c(F)c(F)c1F

HCID86740496

未命名化合物

收率 55.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

1,4,5,6,7,8-Hexahydro-2-methyl-5-oxo-4-(2,3,4,5,6-pentafluorophenyl)-1,7-naphthyridine-3-carboxylic acid methyl ester (5.0 g), 2.3 g of 1,2-epoxy-3-(4-methoxyphenoxy)propane and 125 ml of methanol were combined and refluxed for 18 hours. The solution was saturated with hydrogen chloride, then the methanol was evaporated in vacuo. The residue was crystallized from ethyl acetate. Recrystallization from acetonitrile afforded 4 g of the title compound as the hydrochloride, salt, m.p. 222° C. dec.

WORKUP

后处理

temperaturerefluxed for 18 hours
customthe methanol was evaporated in vacuo
customThe residue was crystallized from ethyl acetate
customRecrystallization from acetonitrile

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-93a2a668bd824d51b6b49afda3c8c0da
来源数据集: uspto-grants-1985_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04551534
来源说明: uspto-grants-1985_11

反应 SMILES

[CH3:1][O:2][C:3]([C:5]1[CH:14]([C:15]2[C:20]([F:21])=[C:19]([F:22])[C:18]([F:23])=[C:17]([F:24])[C:16]=2[F:25])[C:13]2[C:12](=[O:26])[CH2:11][NH:10][CH2:9][C:8]=2[NH:7][C:6]=1[CH3:27])=[O:4].[O:28]1[CH:30]([CH2:31][O:32][C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=2)[CH2:29]1.Cl>CO>[CH3:1][O:2][C:3]([C:5]1[CH:14]([C:15]2[C:16]([F:25])=[C:17]([F:24])[C:18]([F:23])=[C:19]([F:22])[C:20]=2[F:21])[C:13]2[C:12](=[O:26])[CH2:11][N:10]([CH2:29][CH:30]([OH:28])[CH2:31][O:32][C:33]3[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=3)[CH2:9][C:8]=2[NH:7][C:6]=1[CH3:27])=[O:4]