反应详情

Ethyl-3-trifluoromethylcinnamate (0.98 g) (Example 2) in tetrahydrofuran under nitrogen was treated with the ylid prepared from isopropyl triphenylphosphonium iodide (2.12 g) and n-butyllithium (2.8 ml). After 20 hours at 80° the mixture was worked up in the usual manner. Purification by chromatography (silica; ether/hexane) gave (±)-n-butyl-[trans-3-(3-trifluoromethylphenyl)-2,2-dimethylcyclopropyl]-formate (0.78 g). NMR 1H: 7.22(4H,m), 4.20(2H,m), 2.72(1H,m), 2.00(1H,m), 1.40(7H,m), 0.89(6H,m).

1. customPurification by chromatography (silica; ether/hexane)