反应详情

Prepared from 3(S)-amino-3,4-dihydro-1,5-benzothiazepin-4(5H)-one (prepared from D-cysteine (S-cysteine) by the method of Slade, et al, J. Med. Chem., 28, 1517-1521 (1985)) and 3-t-butoxycarbonylamino-3-methylbutanoic acid (Example 31, Step E) by the procedure described in Example 1, Step F. 1H NMR (200 MHz, CDCl3): 1.38 (s,6H), 1.45 (s,9H), 2.32 (d,10 Hz,1H), 2.50 (d,14 Hz,1H), 2.70 (d,14 Hz,1H), 2.92 (t,11 Hz,1H), 3.93 (dd;7,11 Hz;1H), 4.76 (m,1H), 7.02 (d,8 Hz,1H), 7.1-7.3 (m,2H), 7.40 (t,8 Hz,1H), 7.66 (d,7 Hz,1H), 8.23 (br s,1H). FAB-MS: calculated for C19H27N3O4S 393; found 394 (M+H,36%).