Phenethyl bromide → HCID 19766184, compound

HRID 1591454Notes

Reaction equation

HRID 1591454 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:30])([CH3:29])[CH2:13][C:14]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=2[NH:19][C:18]1=[O:28])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:31]1[CH:36]=[CH:35][C:34]([CH2:37][CH2:38]Br)=[CH:33][CH:32]=1>>[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:30])([CH3:29])[CH2:13][C:14]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=2[N:19]([CH2:38][CH2:37][C:34]2[CH:35]=[CH:36][CH:31]=[CH:32][CH:33]=2)[C:18]1=[O:28])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7666Phenethyl bromideHCID 218366093-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide

Product 1

HCID 19766184HCID 19766184, compound

Procedure

Prepared from the intermediate obtained in Step A and 2-phenethyl bromide by the procedure described in Example 3, Step A. 1H NMR (200 MHz, CDCl3): 1.37 (s,6H), 1.68 (m,2H), 2.50 (m,4H), 2.7-3.0 (m,2H), 3.70 (m,1H), 4.48 (m,2H), 5.05 (s,2H), 5.66 (s,1H), 6.99 (m,1H), 7.0-7.4 (m,14H). FAB-MS: calculated for C31H35N3O4 513; found 514 (M+H,100%).

Sources & evidence

ORD record
ord-917da148e03f4311ae0944ae62cd9204
Source dataset
uspto-grants-1993_04
Patent number
US05206235

Reaction notes

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