反应详情

The title A compound, 5-(5-diethoxymethyl-thiophen-2-ylmethyl)-2-(2,4-dimethoxy-benzyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (3.91 g, 8.1 mmol) is dissolved in THF (100 mL) and 6N aqueous HCl (2.7 mL) is added. The mixture is stirred for 2 h and the solvent is evaporated. The residue is partitioned between EtOAc and saturated aqueous NaHCO3 solution. The organic layer is dried over anhydrous MgSO4 and concentrated to dryness. The residue is triturated from Et2O to afford 5-[5-(2,4-dimethoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-thiophene-2-carbaldehyde as a yellow solid.

1. customthe solvent is evaporated
2. customThe residue is partitioned between EtOAc and saturated aqueous NaHCO3 solution
3. dry with materialThe organic layer is dried over anhydrous MgSO4
4. concentrationconcentrated to dryness
5. customThe residue is triturated from Et2O