反应详情

3.0 g (9.1 mmols) of 4-hydroxy-6-(4-nitrophenyl)furo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester are boiled for 50 min in ca. 50 ml of 5% sodium hydroxide solution. The reaction mixture is suction-filtered whilst hot and the residue discarded. [In order to obtain the sodium 4-hydroxy-6-(4-nitrophenyl)furo[2,3-d]pyrimidine-5-carboxylate, the cold filtrate (after cooling, needles form) is filtered by suction over ice and washed with a little ice water. The needles are dried in a HV. M.p. >250° C. (decomposition).] After cooling, the filtrate is carefully adjusted to pH 1 with conc. hydrochloric acid (a precipitate forms). Filtering by suction and drying of the residue in a HV yield the title compound as a solid, which melts at 300-302° C. (decomposition at the melting point):

1. filtrationThe reaction mixture is suction-filtered whilst hot and the residue