反应详情

26.7 g (63 mmole) 4-(tert-butoxycarbonylamino)phenethyl 3-nitro-benzenesulfonate, 8.5 g (69 mmole) p-hydroxybenzaldehyde, 9.54 g (69 mmole) potassium carbonate and acetonitrile was refluxed for 3 hours and thereafter stirred over night at room temperature. The precipitate was filtered off and the solvent was evaporated. Dichloromethane was added and the organic phase was washed with saturated sodium carbonate and thereafter with sodium hydroxide (0.1 M), dried (sodium sulfate), filtered and the solvent was evaporated to give 17 g (yield 79%) of tert-butyl N-{4-[2-(4-formylphenoxy)ethyl]phenyl}carbamate.

1. filtrationThe precipitate was filtered off
2. customthe solvent was evaporated
3. additionDichloromethane was added
4. washthe organic phase was washed with saturated sodium carbonate
5. dry with materialwith sodium hydroxide (0.1 M), dried (sodium sulfate)
6. filtrationfiltered
7. customthe solvent was evaporated