反应详情

The reaction procedure of Example 9 was repeated except that 434 mg (1.27 mmols) of (2S,3S)-3-(t-butoxycarbonylamino) -4-phenylbutane-1,2-diol was used in lieu of 400 mg (1.27 mmols) of (2S,3S)-3-(benzyloxycarbonylamino)-4-phenylbutane-1,2-diol and the reaction product was purified by silica gel column chromatography (hexane/ethyl acetate=2/1) to provide 183 mg (0.887 mmol, yield 70%) of (4S,5S)-5-hydroxymethyl-4-phenylmethyloxazolidinone as crystals.

1. customThe reaction procedure of Example 9
2. customthe reaction product was purified by silica gel column chromatography (hexane/ethyl acetate=2/1)