反应详情

A solution of (±)-(E)-1-(4-(2-phenylethenyl)phenoxy)-4-(3-pyridyl)-2-butanol (0.32 g, Example 61) was dissolved in dry ethanol (50 ml) and hydrogenated for 24 hours at 3 atmospheres using palladium on carbon (10%, 0.1 g) as catalyst. The reaction mixture was filtered through Celite® and the residue washed with ethanol. The filtrate and washings were combined and concentrated under reduced pressure. The residue was purified by column chromatography over silica eluting with dichloromethane:methanol (95:5) to give the title compound as a white solid (0.29 g).

1. filtrationThe reaction mixture was filtered through Celite®
2. washthe residue washed with ethanol
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by column chromatography over silica eluting with dichloromethane:methanol (95:5)