反应详情

A solution of the N-methylmorpholine-N-oxide (22.24) in acetonitrile (250 ml) containing 3 Å molecular sieves (8.71 g) was stirred at room temperature overnight, then cooled in ice. A solution of 4-bromomethyl-7-fluoro-benzofuran (23.45 g) in acetonitrile (50 ml) was added and the mixture stirred for 4 h. The mixture was filtered and the filtrate evaporated to dryness. Water and ether were added to the residue and the organic phase separated, washed with brine (2×200 ml), dried (MgSO4) and evaporated. The residue was triturated under ether (50 ml) and filtered to give the title compound as a pale yellow solid (5.45 g)

1. temperaturecooled in ice
2. stirringthe mixture stirred for 4 h
3. filtrationThe mixture was filtered
4. customthe filtrate evaporated to dryness
5. additionWater and ether were added to the residue
6. customthe organic phase separated
7. washwashed with brine (2×200 ml)
8. dry with materialdried (MgSO4)
9. customevaporated
10. customThe residue was triturated under ether (50 ml)
11. filtrationfiltered