Sodium 5-formylfuran-2-sulphonate → 5-[2-(N-n-Butylcarbamoyl)eth-1-enyl]-furan-2-sulfonic Acid Sodium Salt

Temperature

5 °C

To a suspension of (N-n-butylcarbamoyl)methyltriphenylphosphonium chloride (16.63 g, 40.38 mmol), from Example B above, in tetrahydrofuran (200 mL) at 0-5° C. was added a solution of n-butyllithium in hexanes (18 mL, 2.5 M, 45 mmol). Upon addition of the n-butyllithium solution, the solution became homogeneous and the reaction mixture was stirred for 10 min at 5° C. 5-Formylfuran-2-sulfonic acid sodium salt (8.0 g, 40.38 mmol) was then added in one portion and the reaction mixture was stirred for 45 min at 0-5° C. and then at room temperature for 1.75 h. The mixture was filtered and the solid obtained was stirred with THF (100 mL) for several hours and then filtered. The solid was mixed with ethanol (200 mL) and filtered to remove the undissolved solid. Removal of solvent provided 8.24 g (69.1% yield) of the title compound as a slightly yellowish powder, m.p.=318.1° C. (dec) (Rf =0.55 on a silica gel plate using 2:1 EtOAc/EtOH). This product consisted of 70% trans-isomer and 30% cis-isomer.

1. stirringthe reaction mixture was stirred for 45 min at 0-5° C.
2. waitat room temperature for 1.75 h
3. filtrationThe mixture was filtered
4. customthe solid obtained
5. filtrationfiltered
6. additionThe solid was mixed with ethanol (200 mL)
7. filtrationfiltered
8. customto remove the undissolved solid
9. customRemoval of solvent

ORD record

ord-e591dc7bc2da47dbb05df1c8527980de

Source dataset

uspto-grants-1999_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05994396