反应详情

温度

60 °C

A mixture of 4-tert-butyl-2-[5-(3-chloropropyl)-benzofuran-2-yl]thiazole (0.19 g), 3-cyano-6-methylindole (73 mg), sodium hydroxide (90 mg) and small amount of cetyl trymethylammonium chloride in tetrahydrofuran (1 ml) was stirred at 60° C. for 1 day. After the mixture was cooled to room temperature, the insolble mass was filtered off and the filtrate was concentrated under reduced pressure to give a syrup. The syrup was subjected to column chromatography on silica gel and eluted with a mixture of n-hexane and ethyl acetate. The fraction containing the objective compound were combined and concentrated under reduced pressure to give 4-tert-butyl-2-{5-[3-(3-cyano-6-methylindole-1-yl)propyl]-benzofuran-2-yl}thiazole (90 mg).

1. temperatureAfter the mixture was cooled to room temperature
2. filtrationthe insolble mass was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. customto give a syrup
5. washeluted with a mixture of n-hexane and ethyl acetate
6. additionThe fraction containing the objective compound
7. concentrationconcentrated under reduced pressure