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HRID1604678

反应详情

EQUATION

反应方程式

HRID 1604678 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)c1csc(-c2cc3cc(C(=O)n4cc(C(=O)OCc5ccccc5)c5ccccc54)ccc3o2)n1
HCID19603790

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)c1csc(-c2cc3cc(C(=O)n4cc(C(=O)O)c5ccccc54)ccc3o2)n1
HCID19603721

未命名化合物

收率 83.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A solution of benzyl 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]carbonyl}indole-3-carboxylate (107 mg) in tetrahydrofuran (4 ml) was hydrogenated over 10% Pd--C (22 mg) at room temperature under atmospheric pressure. After removal of the catalyst by filtration, the filtrate was concentrated under reduced pressure to give 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]carbonyl}indole-3-carboxylic acid (74.5 mg).

WORKUP

后处理

  1. customAfter removal of the catalyst
  2. filtrationby filtration
  3. concentrationthe filtrate was concentrated under reduced pressure