反应详情

To 305 mg (0.944 mmol) of ethyl 2,2-dimethyl-3(1-hydroxy-2,2-dichloro-3,3,3-trifluoropropyl)cyclopropanecarboxylate obtained in Example 2, 1 ml of pyridine and 1 ml of acetic anhydride, were added, and the mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, and then purified by column chromatography (silica gel, dichloromethane/hexane=1/1) to obtain 322 mg of ethyl 2,2-dimethyl-3-(1-acetoxy-2,2-dichloro-3,3,3trifluoropropyl)cyclopropanecarboxylate (a mixture of two stereoisomers (55:45)) as a colorless oily substance.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. custompurified by column chromatography (silica gel, dichloromethane/hexane=1/1)