反应详情

The titled compound was prepared substantially in accordance with the method detailed in Example 46 using 2.50 g (0.0107 mol) of 2-amino-N-[2-(1H-imidazol-2-yl)ethyl]benzamide and 4.20 g (0.0213 mol) of meta-t-butylbenzoyl chloride with the exception that, after reducing the organic layer to dryness the resulting residue was dissolved in a 1:7 methanol/ethyl acetate solution. The resulting solution was concentrated until crystals began to form and then diethyl ether was added. The resulting solution was cooled and 2.90 g of the desired titled compound were recovered by filtration (m.p. 205°-210° C.).

1. concentrationThe resulting solution was concentrated until crystals
2. customto form
3. temperatureThe resulting solution was cooled
4. filtration2.90 g of the desired titled compound were recovered by filtration (m.p. 205°-210° C.)