反应详情

The title compound (36 mg, 42%) was synthesized as an orange red solid according to the method described for Example A67 (oil temp 75° C., reflux 90 min) using 5,6-dimethoxyindolin-2-one (38.6 mg, 0.2 mmol) and (E)-3-(2-(pyridin-4-yl)vinyl)-1H-indazole-6-carbaldehyde (49.8 mg, 0.2 mmol). 1H NMR (400 MHz, DMSO-d6) δ 13.54 (s, 1H), 10.39 (s, 1H), 8.60-8.53 (m, 2H), 8.35 (d, J=7.2 Hz, 1H), 7.94 (s, 1H), 7.87 (d, J=16.4 Hz, 1H), 7.75-7.67 (m, 2H), 7.63-7.50 (m, 3H), 7.25 (s, 1H), 6.53 (s, 1H), 3.80 (s, 3H), 3.55 (s, 3H); MS ESI 425.2 [M+H]+, calcd for [C25H20N4O3+H]+ 425.1.

1. customdescribed for Example A67 (oil temp 75° C., reflux 90 min)