反应详情

2.0 ml (2.0 mmol) of a 1N aqueous sodium hydroxide solution were added to 0.29 mg (0.61 mmol) tert-butyl 3-(4-fluorophenyl)-4-(2-methoxy-2-oxoethyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate in 5 ml MeOH. After 1 h at RT MeOH was distilled off and the aqueous solution was acidified with 1N hydrochloric acid. The aqueous phase was extracted with ethyl acetate. The ethyl acetate phase was dried and evaporated down.

1. distillationAfter 1 h at RT MeOH was distilled off
2. extractionThe aqueous phase was extracted with ethyl acetate
3. dry with materialThe ethyl acetate phase was dried
4. customevaporated down