反应详情

To a suspended of 5-amino-7-fluoro-4-((1-methyl-1H-1,2,4-triazol-3-yl)methyl)phthalazin-1-(2H)-one (7) (1.6 g, 5.8 mmol) in acetonitrile (50 mL) was added 4-fluorobenzaldehyde (2.2 g, 17.5 mmol). The mixture was stirred under reflux under nitrogen for 48 hours. The precipitate was filtered and washed with a mixture of solvents (ethyl acetate/hexane, 1:1, 10 mL). After drying in vacuum, it afforded the title compound as a yellow solid (1.2 g, yield 52%). LC-MS (ESI) m/z: 381 (M+1)+.

1. temperatureunder reflux under nitrogen for 48 hours
2. filtrationThe precipitate was filtered
3. washwashed with a mixture of solvents (ethyl acetate/hexane, 1:1, 10 mL)
4. customAfter drying in vacuum, it